Candidate gene-environment interactions.

One of the limitations of interdisciplinarity is the misunderstanding regarding specific words and concepts from one discipline to the other ( ). One way to circumvent this aspect is to incorporate the vocabulary of other disciplines, when it corresponds to the appropriate 1 concept. Gene environment interaction is a popular topic, for which there has been to date, more reviews than established findings. There has been numerous attempts to represent what types of interactions could occur ( ). Geneticists have proposed the term candidate genes to 2 infer there was a specific hypothesis, usually regarding the function of the gene, justifying its study for a given disease, whereas genomewide comparisons have been called agnostic ( ), which etymologically means without knowledge. In that context, testing a “ ” 3 candidate gene-environment interaction is to test a hypothesis, based on knowledge ( ). 4